Hussey, the 26-year-old younger brother of Western Australia's opener Michael Hussey, helped his side recover from a troubled 229 for six wickets to 326 all out as they established a first innings lead, worth two points, of 39 on the second day of the four-day match on Saturday.
New South Wales, who made 287 in their first knock, were 18 for one wicket in the second at stumps, still 21 runs behind.
Hussey, who moved from Perth to Melbourne two years ago to further his cricket career, was well supported by skipper Cameron White (78) and wicketkeeper Peter Roach (46).
Test speedster Brett Lee (3-83) showed that he has fully recovered from injury and is ready to play for Australia in the third Test against India, starting in Melbourne on the Boxing Day.
Dominic Thornely (3-52) and Michael Clarke (3-62) were also in good touch with the ball.