Pakistan, struggling to avoid defeat, were 91 for four in their second innings on day four after being forced to follow-on a placid track at the Multan Cricket Stadium.
Yousuf Youhana was batting on 19 while Abdul Razzaq was on 11 at the tea break, Pakistan still trailing by 177 runs.
In reply to India's mammoth score of 675 for five declared, Pakistan were earlier bowled out in their first innings for 407 with Irfan Pathan returning figures of 4-100.
Skipper Rahul Dravid chose to enforce the follow-on although key fast bowler Zaheer Khan walked off the field after bowling just one over this morning. Team manager Ratnakar Shetty later said that the bowler would not take any further part in the match due to a muscle strain.
Dravid's decision paid rich dividends in the post lunch session with India claiming four crucial wickets including that of captain Inzamam-ul -Haq (0) and first innings top-scorer Yasir Hameed (23).
Leg spinner Anil Kumble was the most successful Indian bowler picking two wickets -- that of openers Imran Farhat (24) and Taufiq Umar (9).