Incidentally, Pakistan played its first Test against India at New Delhi in 1952-53.
"It is a great occasion for us and we will start the day with special prayers to Almighty Allah before entering the ground for our 300th Test," said Pakistan captain Inzamam-ul-Haq.
"We will pray to Almighty to help us win this 300th Test. We have already won both the Tests played at this venue," said Inzamam, a local of Multan who hit two hundreds in the two games hosted so far in Multan.
And one man for whom the 300th Test would be more special is coach Javed Miandad as he featured in Pakistan's 100th Test and 200th Test as well.
The 100th Test is most remembered for Sarfraz Nawaz's 9-86 that helped Pakistan beat Australia at the Melbourne Cricket Ground (MCG) in 1978-79. Miandad led Pakistan to a draw in country's 200th Test, against England at Old Trafford in the 1992 series and his contribution was 88 and 45 in a series won 2-1 by Pakistan.
"It is a great thing to be part of the team in the 100th and 200th Tests and now I am the coach in the 300th Test," said Miandad.
Miandad hoped his side will make the occasion a memorable one by notching up a win.
"We have worked very hard for the match and I hope the boys realise the occasion is great for us. We would do our best to make the occasion a memorable one for the whole nation," said Miandad, who hit a century in his 100th Test when India played at Lahore on their last tour in 1989-90.
Miandad holds the record of scoring most runs for Pakistan at 8832 in another record of 124 Tests. He also holds the record of taking maximum catches for Pakistan at 93. Pakistan has won 92 of their 299 Tests before the Multan game, having lost 74 and drawn 133.