When drinks were taken India were reeling at 163 for seven at the Gaddafi Stadium.
Dravid's decision to bat first Test on a lively track seemed to backfire although Sehwag and Dravid had the Pakistani pacers by the scruff of their neck with an attacking second wicket stand that brought 64 runs.
Mohammad Sami struck the first blow when he rapped Aakash Chopra plumb in front for four in the second over.
Chopra's dismissal with only five on the board saw India lose their opening batsman for less than 50 runs in the first innings for the first time in six Tests.
Sehwag continued from where he had left at Multan cracking six four and a slashed six over backward point off Shoaib Akhtar.
Sami and Akhtar began to lose direction after the early breakthrough and India had 61 runs on board after 10 overs.
But the introduction of Gul, who replaced Shabbir Ahmed, changed the tide.
Gul had Sehwag caught behind by Kamran Akmal with a delivery that held its line. The lanky paceman struck six balls later when he brought one in sharply to have Tendulkar leg before the wicket.
Gul's controlled seam-up bowling was rewarded again when an off-colour Laxman thick edged an away going delivery to Taufiq Umar at second slip.
Earlier, India made one change to their team that won the first Test, Ajit Agarkar coming in for the injured Zaheer Khan.
Pakistan on the other hand made four changes bringing in Asim Kamal, Umar Gul, Danish Kaneria and Kamran Akmal in place of Abdul Razzaq, Shabbir Ahmed, Saqlain Mushtaq and Moin Khan.