They were given a farewell by the Pakistan Cricket Board (PCB), security officials, staff at the hotel and fans at the airport.
Before they left for the airport, the cricketers had a formal meeting with PCB Chief Shaharyar Khan at a conference room of the hotel.
In a brief speech, Shaharyar thanked the cricketers for making the series an important milestone in building people to people contacts between the two countries.
He said the Indians won both the One-day and Test series because they were a better team and also praised their on and off field behaviour which won them many friends in Pakistan.
The PCB chief later presented mementoes to Indian cricket officials.
The team was later seen off at the Islamabad airport by Rawalpindi Mayor Tariq Kiani, PCB General Manager Zakhir Khan and other civil and police officials.
Before they boarded the flight, the Indian cricketers were seen exchanging pleasantries with top Pakistani police official Sohail Khan who coordinated the security arrangements during their nearly 40-day stay in Pakistan.
Tight security arrangements were made at the airport when the Indian cricketers arrived to board their special flight, which left two hours earlier than scheduled as the Rawalpindi Test ended on the fourth day itself.