Davison dazzled the cricket world with record-breaking feats at last year's World Cup in South Africa, scoring the fastest century in the history of the tournament with a stunning 111 from 76 balls against the West Indies at Centurion.
The 34-year-old will make his captaincy debut against Canada's long-standing cricket rival in the three-day match at the Brian Piccolo Park in Florida.
The USA, meanwhile, has named an unchanged side from the one that defeated Canada in their most recent clash at the ICC Six-Nations Challenge in March.
Davison, who did not play in the Six-Nations Challenge, said he is looking forward to taking on the USA and atoning for Canada's defeat in that tournament.
"It is an honour for me to captain Canada in this historic match between two rival nations," said Davison.
A new tournament, the ICC Intercontinental Cup gives leading Associate Member countries exposure to the longer version of the game.
Played across four continents between March and November 2004, it is the first time a first-class competition has been staged for countries below Test match level.
Canada: John Davison (captain), Ashish Bagal, Ian Rillcliffe, Manzoor Chaudhary, Desmond Chumney, Austin Codrington, Sunil Dhaniram, Haminder Dhillon, Zahid Hussian, Don Maxwell, Ashish patel, Zubin Sukari.
Coach: Rupert Gomes.
United States: Richard Staple (captain), Nasir Javed (vice-captain), Rohan Alexander, Aijas Ali, Zamin Amin, Donovan Blake, Jignesh Desai, Howard Johnson, Mark Johnson, Clayton Lambert, Steve Massiah, Charles Reid
Coach: F Bacchus.