Stanley, coach of the Nagapattinam district cricket team, was declared brought dead, sources at a private hospital said, adding the condition of three of the injured was 'critical.'
The accident occurred at Poovathur village in the early hours.
Police sources said the driver had wanted to take some rest and had parked the van on the roadside.
The team was on its way to Chennai from Nagapattinam to take part in an Under-18 tournament.
The Express bus was also proceeding towards Chennai.