At close, Daniel Manohar (31) and Inder Sekhar Reddy (0) were at the crease after opener Nandakishore made 32.
Earlier, the hosts, who were 183 for one overnight, declared their first innings at 461 for 6. Two worthwhile stands -- between Vidyuth Sivaramakrishnan and S.Badrinath who put on 137 runs for the second wicket and a quickfire 134 in 34 overs between centurion S Sharath and Sridharan Sriram for the fourth wicket -- helped Tamil Nadu gain the upper hand.
Vidyuth, who top scored with 130 (239b, 354min, 12 fours and a six) was adjudged leg before to left arm spinner Inder Sekar Reddy. The bowler had earlier dismissed Badrinath (67, 8 fours and a six) caught at silly point.
After the pair had laid a solid foundation, left handed Sharath and Sriram scored at will. Sriram (57) was the first to go when Venkatapathy Raju rapped him on the pads in front. Sharath, who reached his century, also made his exit when he pulled straight into Daniel Manohar's hands at mid-wicket off Reddy.
Captain Badani (55 off 52 balls) and Dinesh Karthick (1) reamined unbeaten as Tamil Nadu declared their innings.
Brief Scores: Hyderabad 163 and 63 for 1 and Tamil Nadu (first innings) 461/6 decl (Vidyuth 130,S.Ramesh 29,Badrinath 67, Sharath 105,Sriram 57,Badani not out 55 and I.S.Reddy 3 for 130).