The Victorians, whose last win here was in 1980-81, trounced Tasmania by 127 runs on Thursday.
Michael Bevan was the last man standing on an unbeaten 167 after more than seven hours at the crease, with Tasmania all out for 366 before tea on the final day.
Fast bowler Michael Lewis finished with 6-84 and a match total of nine wickets.
Skipper Cameron White praised Lewis, who has taken 14 wickets at 12.78 so far this season, and opener Graeme Rummans for his top-scoring 188 in Victoria's second innings.
In Adelaide, Queensland fast bowler Andy Bichel ruined South Australia's slim winning hopes by grabbing three wickets in his first seven overs on a rain-delayed third day.
With South Australia chasing 446 for victory, Bichel took 3-1 in 17 balls as he nailed Greg Blewett (11) and Ben Cameron (0) lbw and had Mark Cosgrove (0) caught behind.
His demolition job had South Australia 26 for four off 12.1 overs.
Jack Smith blasted nine fours in his 57 -- SA's first half-century of the match -- until he was caught off Shane Watson.
At stumps SA were 138 for five, still requiring 308 off at least 112 overs on Friday's final day.
In Hobart (final day): Victoria 162 (I. Harvey 79, M. Inness 24; A. Griffith 7-54) and 432 for 9 declared (G. Rummans 188, B. Hodge 96, D. Hussey 67; A. Downton 5-94, A. Griffith 3-119) beat Tasmania 101 (M. Bevan 19, J. Cox 16, M. Di Venuto 16; M. Lewis 3-13, I. Harvey 3-33) and 366 (M. Bevan 167 not out, D. Wright 111; M. Lewis 6-84).
In Adelaide (day three): Queensland 279 (J. Hopes 57, A. Noffke 44 not out, A. Symonds 44; P. Rofe 5-93) and 316 (J. Maher 80, S. Watson 61, A. Symonds 52; S. Tait 7-99) v South Australia 150 (G. Blewett 37, T. Plant 31; S. Watson 4-25, A. Bichel 4-71) and 138 for 5 (J. Smith 57, C. Ferguson 28 not out, G. Manou 25 not out; A. Bichel 3-23).