At stumps, Andhra had battled their way to 133 for 4 in 65 overs in their second innings, still 266 runs short of making reigning champions and hosts bat for the second time.
Andhra, bundled out in only 55.3 overs - 53 minutes before lunch - to concede a big 399-run first innings lead to the home team, started well after following on by putting on 78 runs for the first wicket before losing four wickets for 16 runs.
Mumbai's lanky left-arm spinner Nilesh Kulkarni grabbed all the four Andhra second wickets to fall in the space of 6.2 overs after going wicketless in the first essay.
The visitors then made a partial recovery through the unfinished fifth wicket stand worth 39 runs between Amit Pathak (59) and Yalaka Gnaneswara Rao (16).
Pathak braved an injured hand that forced him to retire midway through his innings and then resumed to remain unbeaten after a stay of more than three hours during which he faced 130 balls and struck ten fours.
In the morning, Andhra lost their last five wickets for the addition of only 57 runs after resuming at 59 for five.
Brief Scores: Mumbai 515 for 9 decl.
Andhra 116 (M S K Prasad 32, Sairaj Bahutule 3 for 43) and 133 for 4 (L N P Reddy 33, Amit Pathak batting 59, Y Gnaneswara Rao batting 16, Nilesh Kulkarni 4 for 32).