Brett Lee will spearhead the Australian's impressive pace attack that also includes tearaways Shaun Tait and Lewis, along with local favourite Damien Wright, for the back-to-back weekend games at Hobart's Bellerive Oval.
Lee is certain to be named in the senior Australian squad for the opening triangular one-day series games starting on January 14.
The others have the chance to impress against the West Indies, who were thrashed by seven wickets by Victoria state in their tour opener at the Melbourne Cricket Ground on Wednesday.
"We've said we're going to test them out a bit," Lewis said.
"We started out the other night for Victoria and hopefully we can continue it here. We've got a good attack so anything could happen. We've been selected to play for Australia A and everyone is treating it that way, it's a big honour for everyone."
"If we can put the wind up and get a psychological edge on them that's great and hopefully when they play the senior side the scars will be there for them."
Lewis claimed two wickets for the Victorians in this week's win, but only after being on the receiving end of a Chris Gayle cameo.
The West Indies opener smashed 18 runs off Lewis's second over before the Victorian had him caught at short fine leg two overs later for a whirlwind 33.
"It looked like he went out there and just backed his eye and hit through the line of the ball and I think that's the way they play, they just back themselves and play their shots," said Lewis.
"They started off like that, but when it got to the middle order and it got a bit tougher they lost their way a little bit."
The West Indies on Friday would not confirm whether Brian Lara would play in Saturday's match, although the Test innings record holder may well miss at least one of the weekend's games in Hobart as he has been picked in the World XI for Monday's game at the MCG to raise funds for victims of the Indian Ocean tsunami.
"If Brian plays, well and good, but we've got a job to do," said Australia A skipper Brad Haddin.
"Traditionally Australia A have had a good record against touring teams and... we don't want to change that.
"We want to continue the success of Australia A and make it as difficult for opposition teams to get into the tour as possible. If you get beaten by the Australia A team it can play in the back of your minds."
West Indies (from): Brian Lara (capt), Chris Gayle, Wavell Hinds, Ramnaresh Sarwan, Shivnarine Chanderpaul, Marlon Samuels, Ryan Hinds, Dwayne Bravo, Courtney Browne, Ian Bradshaw, Mervyn Dillon, Pedro Collins, Reon King, Xavier Marshall.
Australia A (from): Brad Haddin (capt), Michael Hussey, Nathan Hauritz, James Hopes, Brad Hodge, David Hussey, Brett Lee, Michael Lewis, Marcus North, Shaun Tait, Dominic Thornely, Cameron White, Damien Wright.