Responding to Victoria's paltry first innings of 155, Western Australia reached 414 for 6 at stumps -- a lead of 259 runs with two full days remaining in the four-day match at the Western Australian Cricket Association ground on Monday.
It was Hussey's second double century this season -- the first being his best score for the state of 210 against Tasmania in October.
He was dropped on 131 by Shane Warne at slip midway through Monday's second session, but it was the only chance he offered.
Hussey's commanding knock included 31 boundaries.
Victoria's attack was disappointing, failing to make any significant inroads with pacemen Allan Wise taking 1-69 and Michael Lewis 2-81 while Warne with 1-84 and skipper Cameron White on 1-67 also struggled on the flat WACA pitch.