Hussey hit an unbeaten 165 to leave Durham in control on 325 for three against Leicestershire in the Division Two match at Grace Road.
Hussey hit 23 fours and two sixes as he carried his bat for the day.
Former England batsman Graeme Hick hit 80 as Worcestershire made steady progress against Derbyshire at the County Ground.
The visitors elected to bat but early losses, including that of new captain Vikram Solanki for a duck, put the visitors in trouble.
But Hick, opener Stephen Peters (55), Ben Smith (48) and Gareth Batty (47) took Worcestershire to 305 for six.
Will Jefferson became the first Englishman to score a century this season after Essex were forced to make a late start because of rain against Yorkshire at Chelmsford.
Jefferson lost opening partner Alastair Cook with the total on 32 but then became the next wicket to fall with the total on 220 after scoring 149.
Jefferson hit 24 boundaries in his innings and Zimbabwe's Grant Flower was unbeaten on 55 as the home side were 224 for two when bad light forced a premature finish.
Mal Loye's half-century was the only bright spot as promotion favourites Lancashire struggled against Somerset at Old Trafford.
Loye scored 53 as the Somerset attack shared the wickets around, restricting their hosts to 235 for seven by the close.
Former England all-rounder Dominic Cork held Lancashire's hopes of adding significantly to their total after building a patient unbeaten 28.
In Division One England spinner Ashley Giles put champions Warwickshire in charge against Glamorgan but there was no dream start for his One-day international team-mate Kevin Pietersen.
South African-born Pietersen had been expected to make his debut for Hampshire but failed to recover from a foot injury in time for the start of the home match with Gloucestershire.
There were no problems for Giles at Edgbaston as he claimed six wickets as the visitors were reduced to 198 all out.
Giles, recently named one of the Wisden cricketers of the year for 2004, finished with an impressive six for 44 off 17.3 overs.
Giles struck the important blow to end former Australian Test batsman Matthew Elliott's hopes of scoring the first century of the season.
Elliott was bowled after scoring 84 runs, including 14 boundaries of which one was a six.
But with only three other batsmen in double figures the Welsh county hardly set the Bears a worthwhile target.
Openers Nick Knight and Mark Wagh were unbeaten on 41 and 27 respectively from a response of 68 when bad light stopped play, bringing a premature end to proceedings.
In contrast to Giles his England team-mate Pietersen had to sit and watch as new county Hampshire, who he joined from Nottinghamshire in the close season, struggled against Gloucestershire.
Hampshire were bowled out for a paltry 197 thanks in main to an unbeaten 72 from Simon Katich. Michael Brown (35) was the next best batsman.
Gloucestershire's Jon Lewis, on the fringes of the England team in South Africa over the winter, claimed three wickets.
Mark Hardinges also claimed three victims and Steve Kirby, a winter recruit from Yorkshire, took two wickets.
Gloucestershire were going well at 118 for two at the end of the day with Phil Weston (66) and Craig Spearman (34) leading the way, to trail by 79 runs.
Michael Yardy confirmed his liking for the Surrey attack as he underpinned a promising Sussex total on a rain-reduced opening day at The Oval.
Yardy, given an opportunity to make a name for himself at number three, took no chances after the departures of openers Ian Ward and Richard Montgomerie - keeping out 120 balls from which he hit six fours towards a hard-working, unbeaten 44 out of 171 for four.
The compact left-hander kept Surrey at bay and put himself on the verge of a half-century to go with his solitary first-class hundred, made against the same opponents last season.