Durham skipper Hussey, who resumed on 165, faced 426 balls with three sixes and 33 fours before he was finally caught by Aftab Habib off Darren Masters.
Durham eventually declared on 523 for eight on the second day of their Second Division fixture at Grace Road on Thursday.
Leicestershire were then bowled out for 123, with pace bowler Liam Plunkett taking five for 43. The hosts were forced to follow-on, ending the day 390 runs behind.
In the top flight county champions Warwickshire saw Michael Powell make 144 and England contender Ian Bell strike 96 against Glamorgan at Edgbaston.
The Bears began the day with a deficit of 130 runs but Bell, hoping to regain a place in the England Test team, was in good touch before falling lbw to ex-England off-spinner Robert Croft.
Warwickshire will resume on 415 for four, a lead of 217 runs.
At The Oval, left-hander Michael Yardy hit 111 as Sussex were bowled out for 370 against Surrey with the home side six for one in reply when rain ended play.
Elsewhere former Sussex seamer Billy Taylor gave Hampshire hope before Gloucestershire regained control at the Rose Bowl.
Taylor took three wickets as the visitors were held to 221 - a first innings lead of just 24. But Hampshire suffered their second batting collapse of the match and were 111 for six at the close with captain and Autstralian leg-spin great Shane Warne 14 not out at the close.
In the Second Division, a stand of 94 between former England all-rounder Dominic Cork (65) and pace bowler Sajid Mahmood (57) helped Lancashire build a total of 323 against Somerset at Old Trafford.
The home pair were then in the wickets as Somerset were reduced to 193 for seven with only England one-day international Ian Blackwell, 74 not out, offering much resistance before bad light stopped play.
England fast bowler Matthew Hoggard collected the wickets of Grant Flower and Ravinder Bopara as Essex, in the mere 32 overs that were possible at Chelmsford, moved on to 327 for four in their first innings against Yorkshire.
There was more progress in the match between Worcestershire and Derbyshire at Derby where visiting captain and England batsman Vikram Solanki let his side bat on briefly before declaring on 350 for nine after Graeme Hick made 80 on Wednesday.
His bowlers then shot out Derbyshire for 135, seamer Alamgir Sheriyar taking three for 48. The hosts were 10 without loss in their second innings, 205 runs behind at stumps.