Akhtar enhanced his comeback chances for Pakistan's series against the West Indies next month with his 5-23 in four overs, having missed Pakistan's recent tour of India due to a hamstring injury.
"I am feeling great. I hope it will help my comeback," said the 29-year-old on Monday.
Captained by Akhtar, the Rawalpindi Rams dismissed Quetta Bears for a paltry 101 after setting a target of 198.
Twenty20, in which sides play 20 overs each, was introduced in England two years ago and has proved a huge success, attracting more crowds than some normal matches. Pakistani cricket chiefs hope it will catch on here.
Pakistani selectors said they would assess the fitness of Akhtar and two other pacers -- Shabbir Ahmed and Umer Gul -- before deciding the West Indies-bound squad next week.
Khan, a wicket-keeper batsman who played 69 Tests and 219 one-dayers before he was discarded last year, hit six sixes and eight boundaries in his 59-ball 112 to give another reminder to the selectors.
Pakistan play three One-dayers and two Tests on their tour of the Caribbean.