"Once we set up a process, we must respect the integrity of that process. If we try to change it each time because someone does not like the decision, then it will be meaningless," Mani was quoted as saying by a Dubai daily on Thursday.
Mani said the ban on Ganguly was in accordance with the regulations approved by the member countries and as such the punishment was neither mild nor harsh.
"As per the rules, one can be banned for minimum of four matches or a maximum of eight matches. Ganguly got a middle-level ban," he said.
Ganguly was banned for six One-Day Internationals following India's slow over-rate twice during the home series against Pakistan.
Asked if the punishment was a bit too harsh he said: "This decision was taken by the match referee and hence I cannot comment on it."
Mani, who was in Dubai for the ground breaking ceremony of the new ICC headquarters, said the ICC will become a more efficient body when it starts operating from Dubai.
"We wanted all our units to be working under one roof. The ICC will be a more efficient and effective organisation when all our units starts operating from Dubai," he said.