Both have two points each from their first encounter against Delhi and defending champions Railways, respectively, which did not yield result.
Karnataka will miss ace spinner Anil Kumble who had taken three wickets in Delhi's first innings at Karnail Singh Stadium in the national capital last week.
The Karnataka spinner is in the Indian team that's slated to take on Sri Lanka in the first test commencing at Chennai on December two.But the home team is not unduly worried. Karnataka skipper Sujith Somasundar said his team is confident of performing well against the visitors.
Mumbai are also upbeat.Captain Nilesh Kulkarni is happy about his team's excellent batting display against Delhi.
Wassim Jaffer's 267, Amol Mazumdar's 95 and Nishit Shetty's 87 has boosted the confidence of Mumbai which piled up 551 against Delhi.
"We have made good preparations. We had a good match against Delhi," said Mumbai's coach Karsan Ghavri, who was all praise for Jaffer and the other batsmen.