Both have two points each from their first encounter against Delhi and defending champions Railways, respectively, which did not yield result.
Karnataka will miss ace spinner Anil Kumble who had taken three wickets in Delhi's first innings at Karnail Singh Stadium in the national capital last week.
The Karnataka spinner is in Team India that's slated to take on Sri Lanka in the first test commencing at Chennai on December 2.
But the home team is not unduly worried. Karnataka skipper Sujith Somasundar said his team is confident of performing well against the visitors.
Mumbai are also upbeat. Captain Nilesh Kulkarni draws heart from excellent batting display that the team put up against Delhi.
Wassim Jaffer's 267, Amol Mazumdar's 95 and Nishit Shetty's 87 has added to the confidence levels of Mumbai, who had piled up 551 against Delhi.
"We have made good preparations. We had a good match against Delhi", said Mumbai's coach Karsan Ghavri, who was all praise for Jaffer and other batsmen of the team.