In the other matches of the day in the South Zone group, Tamil Nadu beat Kerala by 49 runs and Karanataka won against Hyderabad by 72 runs.
Andhra, which won the toss and elected to bat, made an impressive 303 for three in their stipulated overs against a weak Goan bowling attack.
Following their batsmen's exploit, Andhra bowlers also rose to the occasion to bundle out Goa for 139 runs and help their team garner five points, including a bonus point.
In the second match played at Rajiv Gandhi International Cricket Stadium here, Karnataka, who was asked to bat after losing the toss, made 260 for 8 with C Raghu garnering 117 runs that included four boundaries and a six.
In reply, Hyderabad could make only 188 for nine with former Indian turner Sunil Joshi claiming 3 wickets for 28 runs and B Akhil, two wickets for 29 runs for Karnataka.
Karnataka has five points through the bonus point it bagged from the win.
In the third match of the day played at Gymkhana Grounds, Tamil Nadu beat Kerala by 49 runs and earned four points.
Tamil Nadu that hit 304 for six, thanks to Vidyut Sivaramakrishna's 93, kept Kerala to 255 for eight.
For TN, Hemang K Badani made 74 (not out) which included two fours and two sixes in 65 balls.