All-rounder Flintoff took over the captaincy from Vaughan in India and led England to a highly creditable 1-1 Test series draw in a campaign where the tourists were without several key players because of injury and illness.
And with Vaughan's knee injury still keeping the Yorkshire batsman on the sidelines, Flintoff is set to lead the team on home soil in the first Test against Sri Lanka starting at Lord's here Thursday.
"Getting the chance to captain your country is always an honour and it's something I want to do more often to be honest," the 28-year-old Lancashire star said.
"To have the chance to do it at Lord's this week is going to be fantastic. To lead the side out at Lord's, the home of cricket, in a Test match, I don't think you could ask for anything more," he also told Sky Sports.
With England quicks Stephen Harmison (shin), Simon Jones (knee) and James Anderson (back) all missing through injury, England could hand a debut to in-form Gloucestershire seamer Jon Lewis.
The 30-year-old took nine wickets in England A's conclusive win over Sri Lanka and last week and conditions could be ideal for Lewis in what will be the earliest Test match ever staged in England, on May 11.
"Lord's is always a special place to play," Lewis said. "I've played some big one-day finals there for Gloucestershire and they've gone well. I feel comfortable at Lord's and comfortable with the surroundings. It's the best ground in the world.
"To play any game at Lord's is a pleasure and an honour so to play for England there would be even more of one."