West Indies have made three changes to their side, bringing Wavell Hinds, Dwayne Smith, and Corey Collymore into their side for Runako Morton, Shivnarine Chanderpaul, and Jerome Taylor.
India have just one change, Yuvraj Singh replaces Venugopal Rao.
West Indies lead the five-match series 2-1, after winning Tuesday's third ODI at Basseterre by four wickets with one ball to spare.
India won the series opener at Kingston by five wickets with one ball to spare, and West Indies rebounded to prevail by one run with two balls to spare in the second ODI at the same venue.
The ODI series concludes on Sunday at Queen's Park Oval.
It will be followed by a four-Test series with matches at St. John's, Gros Islet, Basseterre which is staging a Test for the first time, and Kingston
West Indies: Brian Lara (captain), Christopher Gayle, Marlon Samuels, Ramnaresh Sarwan, Wavell Hinds, Dwayne Bravo, Dwayne Smith, Carlton Baugh Jr., Ian Bradshaw, Corey Collymore, Fidel Edwards.
India: Rahul Dravid (captain), Virender Sehwag, Yuvraj Singh, Mohammed Kaif, Suresh Raina, Irfan Pathan, Mahendra Singh Dhoni, Ramesh Powar, Harbhajan Singh, Ajit Agarkar, Shanthakumaran Sreesanth.
Umpires: Billy Doctrove, Simon Taufel, TV Umpire: Steve Bucknor, Reserve: Terence Birbal.
Match Referee: Chris Broad.