The 27-year-old Welshman was one of the driving forces behind England's Ashes victory last summer - when he was unavailable for only the final Test at The Oval - but he has played little cricket since then.
England and Wales Cricket Board chief medical officer Peter Gregory broke the bad news about Jones when the 15-man squad for the forthcoming series against Ireland and Sri Lanka was announced this afternoon.
Gregory explained: "Simon Jones underwent keyhole surgery yesterday in the United States on his left knee. The rehabilitation from this surgery must be taken slowly to give Simon the best chance of a good result.
"At this stage, we do not expect Simon to be bowling for at least five months - which makes his participation in the Ashes extremely unlikely."