The deposed Team India captain, who had to retire after being hit by a Sahid Nazir bouncer in a tour match against Pakistan last week, managed just one hit to the fence before Ryan Sidebottom got him caught at the cover boundary by Graeme Swann.
Northamptonshire were chasing 213 -- after Nottinghamshire opted to bat first in the match -- and were held at 150 for six in their 20 overs.
Earlier, David Hussey smashed a 34-ball 71, which included five sixes and five fours, and shared a 121-run stand with Samit Patel as Notts ripped apart the Northants bowling.
Ganguly also came in for some thrashing as he was hit for 39 runs in his three overs. Though he did manage to take one wicket but the effort was not enough to compensate for the beating he received.
His figures read 3-0-39-1.
Chasing the formidable target, Northants kept losing wickets at regular intervals, which did not allow them to accelerate their scoring and a defiant unbeaten 72 by Lance Klusener -- studded with five sixes -- was the only consolation for the team.