The visiting side failed to win a single match in the series and were whitewashed 0-4 as the second match in Shenley had to be called off due to bad weather.
The Indians opted to bat first after winning the toss and were dismissed for a paltry 131 in 47.4 overs. England hardly had any trouble in coasting to victory with over 12 overs and seven wickets to spare.
Anjum Chopra was the only Indian to put up some resistance as she top-scored with a patient 44 but the rest of the Indian batting collapsed once again.
Skipper Mithali Raj, who had been in fine form until now, also failed in the face of some good bowling by Jenny Gunn and Isa Guha.
The visitors lost their first wicket with just one run on board as Monica Sharma was bowled by Laura Marsh for nought. Mithali followed Monica and within 17 minutes of the opener's dismissal, the skipper also departed for 12.
Wickets kept tumbling but Anjum stood tall among the ruins and was the eighth wicket to fall after a 118-ball innings, which included four hits to the fence.
The rest of the batting line-up failed to contribute anything significant.
For the home side, Isa and Jenny finished with three and two wickets respectively.
Chasing 132 to win, Laura Newton (41) and Claire Taylor (35) gave the English a fine start and skipper Charlotte Edwards (29 not out) stayed till the end to take the hosts to another comfortable win.
Preeti Dimri was the pick of the Indian bowlers with two wickets in her 10-over spell.
The teams will now go to Taunton for the second Test match starting August 29 after a draw in the first match.
Brief Scores: India: 131 all out in 47.4 overs (Anjum Chopra 44, Isa Guha 3/22, 2/15) England: 132 for three in 37.5 overs (Laura Newton 41, Preeti Dimri 2/21)