A third member, a doctor with doping expertise, will be appointed on Thursday meaning that the hearing could start possibly as early as this week, PCB chairman Nasim Ashraf said Wednesday.
The tribunal will be chaired by barrister Shahid Hamid, who represented former Pakistan player Salim Malik during a match-fixing inquiry in 1998 but left midway through the case. Malik was given a lifetime ban in 2000.
New-ball pairing Akhtar and Asif were sent home from the Champions League in India on Monday after testing positive for the banned steroid nandrolone. They are waiting for the results of 'B' samples.
"Shoaib and Asif are likely to appear before the tribunal later this week," cricket chief Ashraf told a press conference in the southern city of Karachi.
"On the recommendation of the tribunal and of the overall findings we will take action. The responsibility is on the alleged offenders (to prove their innocence) because it is an individual act," he said.
The minimum penalty for a first doping offence under International Cricket Council (ICC) rules is a two-year ban but ICC chief Malcolm Speed had told the PCB the punishment was an "internal affair", Ashraf said.
"The PCB will make a final decision," he told reporters.
"We will allow the players to see their reports. We will definitely share the evidence with them and with their attorney and have already conveyed them about the implications of a failed test," he added.
But the PCB chief sounded a note of caution over earlier comments by medical experts that the two bowlers could claim the nandrolone in their samples was produced through exercise or diet.
"I am a doctor myself and know the intricacies of doping," he said.
"The threshold of a positive test is two nanograms of a substance and WADA (World Anti-Doping Agency) has approved this level, because they are 95 percent confident that when at least an players overexercise or take high protein diets they come under two nanograms."
Ashraf vowed on Tuesday to take a zero tolerance approach to doping, while adding that Akhtar and Asif would be allowed to fight their cases through checks on their 'B' samples.