Skipper Brian Lara was unbeaten on 27 from 54 balls after wicketkeeper Denesh Ramdin became leg-spinner Danish Kaneria's second victim on the stroke of lunch.
Lara was made to rue his decision to bat first as Nazir exploited the overcast and murky conditions to rip through the top order with the wickets of Chris Gayle, Ramnaresh Sarwan and Shivnarine Chanderpaul.
His burst left West Indies tottering on 52 for four before Lara held fort hitting three fours putting on 44 with Dwayne Bravo (32).
Playing only because of the doping ban on strike bowlers, Shoaib Akhtar and Mohammad Asif, Nazir took 3 for 27.
Kaneria also picked up Bravo after Umar Gul had broken an opening stand of 41 between Gayle and Daren Ganga.
Gayle was in blazing form stroking six punishing boundaries in his 28-ball 34.
In the first over from Gul he hit two leg-side fours and then in the ninth over he hit three successive boundaries.
On the fifth ball of the same over, Gul had Ganga caught smartly by Younis at second slip for three.
Nazir then won a fortunate leg before decision against Gayle, who was hit on the thigh roll and given out by umpire Asoka de Silva for 34.
Nazir had Sarwan caught by Younis in the slips and then made it 52 for four in the 14th over by trapping Chanderpaul in front of the wicket for five.
Lara also survived two confident leg before appeals from Nazir before settling down as Bravo holed out to mid-off and Ramdin fell caught at mid-wicket for 12.