The home team was without prolific batsman Mohammad Yousuf, who was with his pregnant wife in Lahore. Yousuf accumulated 665 runs in Pakistan's 2-0 win in the three-Test series which preceded the one-day matches.
Left-arm spinner Abdul Rehman was included to make his international debut for Pakistan.
The tourists had to leave out their ace batsman Shivnarine Chanderpaul due to a slight knee injury, which made way for emerging opener Lendl Simmons to make his one-day debut.
The 21-year-old Simmons is the nephew of former opener Phil Simmons.
The first of the five-match series was washed out due to rain in Rawalpindi.
Pakistan: Inzamam-ul-Haq (capt), Imran Farhat, Mohammad Hafeez, Younis Khan, Shoaib Malik, Abdul Razzaq, Kamran Akmal (wk), Rao Iftikhar, Rana Naved-ul-Hasan, Umar Gul and Abdul Rehman
West Indies: Brian Lara (capt), Chris Gayle, Lendl Simmons, Daren Ganga, Marlon Samuels, Runako Morton, Dwayne Smith, Denesh Ramdin (wk), Ian Bradshaw, Corey Collymore and Jerome Taylor
Umpires: Daryl Harper (Aus), Aleem Dar (Pak) and Television umpire: Zameer Haider (Pak)
Match referee: Alan Hurst (Aus)