Earlier, resuming at their overnight score of 267 for eight, the home team managed to swell their score to 325 in 106.4 overs.
Uttar Pradesh began their reply on a bad note losing opener R Srivastava (four) in the fifth over.
However, S S Shukla (32, 140 balls, 5x4) and Md Kaif (88, 161 balls, 12x4, 2x6) steadied the innings with a 127-run stand for the second wicket in 44.1 overs, After the exit of Kaif and Shukla in quick succession, Suresh Raina compounded the woes of the Tamil Nadu bowlers with a 38 run stand for the fourth wicket with Piyush Chawla (15, 33 balls 2x4) before the latter fell towards the fag end of the day.
Tamil Nadu (First innings): 325 (R Prasanna lbw b Kumar 134, S Sharath lbw b Kumar 25, R Sathish c Raina b Kumar 32, Mahesh lbw b Singh 26, R Ashwin (not out) 42)
Uttar Pradesh (first innings): 204 for four wkts in 71 overs (Shukla lbw b Naresh 32, M Kaif lbw b Naresh 88, S K Raina (batting) 33) UNI