India, leading 2-0 in the four-match series, rested Sourav Ganguly, Harbhajan Singh, Mahendra Dhoni and Zaheer Khan for the day-night clash.
Yuvraj Singh, fit again after suffering a knee ligament injury in November, returns to the team along with veteran spinner Anil Kumble.
Lara was back after missing the previous match in Cuttack on Wednesday with a sore knee.
The tourists rested in-form batsman Shivnarine Chanderpaul and brought in Lendl Simmons and rookie all-rounder Reyad Emrit.
India: Rahul Dravid (capt), Gautam Gambhir, Sachin Tendulkar, Robin Uthappa, Yuvraj Singh, Dinesh Karthick (wk), Suresh Raina, S Sreesanth, Ajit Agarkar, Anil Kumble and Ramesh Powar.
West Indies: Brian Lara (capt), Chris Gayle, Lendl Simmons, Marlon Samuels, Runako Morton, Denesh Ramdin (wk), Dwayne Bravo, Dwayne Smith, Reyad Emrit, Daren Powell, Jerome Taylor.
Umpires: Billy Bowden (NZ) Suresh Shastri (Ind) and TV umpire: Amiesh Saheba (Ind)
Match referee: Alan Hurst (Aus)