Set a modest target of 144 in 50 overs, Karuna (51, 79 balls, 6x4) and left hander Jaya (66, 109 balls, 8x4, 1x6) made mincemeat of the English attack as the home team romped home with 11.1 overs to spare.
Karuna and Jaya added 126 for the opening wicket in 30.2 overs to dash the hopes of the Englishwomen. Though they fell in quick succession, skipper Mithali Raj (12 not out, 2x4) and Kamini (two not out) steered the team home as India finished at 144 for two in 38.5 overs to complete a comprehensive win.
Earlier, England put into bat lost wickets at regular intervals and fell to the guiles of Amita Sharma, whose four wicket haul fetched her the Eve of the match award.
Having lost their first three games, England desperately needed a win to remain in contention for the final, But they suffered a set back even before entering the ground when opener Caroline Atkins and left-arm spinner Holly Colvin were ruled out due to injuries.
They were replaced by medium pacer Lynsey Askew, who made her debut today, and wicket-keeper Jane Smit.
England's woes were compounded as they lost the toss and were asked to make first use of the wicket, which gave some help for the medium pacers.
Exploiting the conditions to the hilt, the Indian seamers bowled a nagging length and picked wickets regularly. England were reeling at 67 for seven in 29.3 overs as Amita ripped through the middle order after medium pacers Jhulan Goswami and Rumeli Dhar prised out both the openers.
However, left hander Lydia Greenway came up with an unbeaten half century (50 not out, 76 balls, 6x4, 1x6) to lent some substance.
Lydia with assistance from the tailender Askew (24, 38 balls, 2x4, 1x6) helped the team to 143 in 45.5 overs.
However, India made light of the target and cantered home with an easy win, with plenty of overs to spare.
England 143 all out in 45.5 overs (Greenway 50 n o, Askew 24; Amita Sharma 4 for 16, Priti Dimri 2 for 26, Jhulan Goswami 1 for 24, Sunetra Paranjpe 1 for 17) lost to India 144 for 2 in 38.5 overs (Jaya Sharma 66, Karuna Jain 51; Isha Guha 1 for 32) by 8 wickets.