The West Indies, needing to win all three of their remaining Super Eight matches to keep their chances of reaching the semi-finals alive, hoped to take advantage of expected lively bowling conditions early in the day on a new pitch.
There were three changes from the West Indian side that lost by 113 runs against Sri Lanka in Guyana in their most recent match nine days ago.
Local favourite, Grenada batsman Devon Smith, replaced Marlon Samuels, while Kieron Pollard and Corey Collymore came in for Dwayne Smith and Jerome Taylor.
South Africa included batsman Herschelle Gibbs, who suffered a calf strain during his team's shock loss against Bangladesh in Guyana Saturday.
South Africa, who have gained one more win than the West Indies in the Super Eight phase but also might need to win all their last three matches, made two changes.
Batsman Loots Bosman replaced Justin Kemp, while all-rounder Andrew Hall returned in place of Charl Langeveldt.
After early morning showers, the sun was shining brightly but there was expected to be some dampness in the pitch to help the seam bowlers.
South Africa: Graeme Smith (captain), Loots Bosman, Jacques Kallis, Herschelle Gibbs, AB de Villiers, Ashwell Prince, Mark Boucher (wk), Shaun Pollock, Andrew Hall, Andre Nel and Makhaya Ntini. Coach: Mickey Arthur
West Indies: Brian Lara (captain), Chris Gayle, Devon Smith, Shivnarine Chanderpaul, Ramnaresh Sarwan, Dwayne Bravo, Denesh Ramdin (wk), Kieron Pollard, Ian Bradshaw, Daren Powell and Corey Collymore. Coach: Bennett.
Umpires: Mark Benson (Eng), Daryl Harper (Aus) and Third umpire: Aleem Dar (Pak).
Match referee: Chris Broad (Eng)