Samuels headlines the list of four active players who took part in the World Cup who have missed out on the trip to England, the others being Kieron Pollard, Lendl Simmons and Dwayne Smith, while Brian Lara has retired.
Samuels, who played in eight of the Windies' nine World Cup matches at an average of 30, is at the centre of an ICC and police investigation into alleged links with an Indian bookmaker, but no reasons were given by the West Indies board as to why he was omitted from the squad.
Fidel Edwards, Daren Ganga, Sylvester Joseph, and Runako Morton have been recalled after missing out on World Cup selection.
Also included are the uncapped Ravi Rampaul and Darren Sammy, while the claims of Pedro Collins and Jermaine Lawson, two more members of "the old guard", have been overlooked.
"We have made some changes, and we feel we have the right mix, and we are hoping that this mix will start the ball rolling as far as the redevelopment or redefining of West Indies cricket for the future," said convenor of selectors, Gordon Greenidge.
"We don't want to have players totally out of their depth. We want to know that we can still compete even if we do not win the series, at least give a good account of ourselves."
A different squad will be named for the two Twenty/20 games and three one-day internationals.
Ramnaresh Sarwan (capt), Dwayne Bravo, Shivnarine Chanderpaul, Corey Collymore, Fidel Edwards, Daren Ganga, Christopher Gayle, Sylvester Joseph, Runako Morton, Daren Powell, Denesh Ramdin, Ravi Rampaul, Devon Smith, Darren Sammy, Jerome Taylor
West Indies tour of England schedule
May 12-14: v Somerset, Taunton
May 17-21: v ENGLAND, 1ST TEST, Lord's
May 25-29: v ENGLAND, 2ND TEST, Headingley
Jun 01-03: v MCC, Durham
Jun 07-11: v ENGLAND, 3RD TEST, Old Trafford
Jun 15-19: v ENGLAND, 4TH TEST, Riverside