Warne, the world's leading Test match wicket-taker, took four for 28 as his Hampshire side handed out a 285-run hammering to Worcestershire at the Rose Bowl in Southampton.
Worcestershire were set an unlikely target of 473 to win, with only Graeme Hick's 69 showing some resistance as his side crumbled to 187 all out.
Warne dismissed Steven Davies (28) and Gareth Batty (10) before Roger Sillence, who made 28 in a seventh-wicket stand of 70 with Hick, was caught at short-leg off the last ball before lunch to send Worcestershire in at 165-7.
Warne struck again on the resumption with a smart pick-up and direct hit to run out Kabir Ali.
Hick was ninth out, edging Warne to slip.
Championship leaders Sussex were struggling in their clash with Warwickshire at Hove despite former Pakistan Test star Mushtaq taking 7-111 as Warwickshire made 238 in their second innings.
That left Sussex needing 504 to win. They were 160-1 at stumps heading into the final day.
Mushtaq's 11-wicket match haul took his season's tally to 69.