India won a three-match series 1-0 after the final Test at The Oval ended in a draw. It might have been different for England had they taken the one wicket they needed for victory in the series opener at Lord's and won the toss at Trent Bridge, where India's seven wicket success ultimately proved decisive.
Vaughan though was in no mood to seek solace in any such excuses.
"There are series that you lose where you know you've played really bad cricket, and there are series like this one where you think you haven't played that badly," he told reporters.
"But in a three-match series, the team that plays better cricket wins, and the way India played the last two games, they picked the series."
England though were without the injured pace trio of Matthew Hoggard, Stephen Harmison and Andrew Flintoff for all three Tests.
However, England will hope to have the three bowlers fit by the time they fly to Sri Lanka in November for their next Test series.
In the meantime the likes of tall fast bowler Chris Tremlett, whose first three Tests yielded 13 wickets at a highly creditable average of under 30 apiece, suggested there will still be competition for places when all of England's seamers are fit.
"I'd like to have all the senior bowlers back for selection," said Vaughan. "They have invaluable experience at this kind of level."
However, he added: Our young bowlers have been asked to bowl at some of the best batsmen in the world, and if you'd said Sourav Ganguly, Rahul Dravid, Sachin Tendulkar and VVS Laxman wouldn't get a hundred (in the series) I'd probably have ripped your hand off.
"Yes, we've lost 1-0 but that's exactly what happened, so all the bowlers deserve credit."
In one respect this series was something of a throwback with swing bowlers on both sides making top order batsmen work hard for their runs.
That was particularly true of the India left-arm duo of Zaheer Khan and Rudra Pratap Singh, a rare combination in modern cricket
"We've been up against a very good Indian team," said Vaughan. "We've been asked different questions against the left-arm angles which we haven't seen before, while our bowlers were up against some of the best batsmen to have played the game. With these kind of experiences, it's important you learn from them and the mistakes you make when you lose."
England, on the backfoot at The Oval after conceding a huge total of 664 in the first innings, at least ensured India didn't win the series 2-0 with the last day enlivened by Kevin Pietersen's tenth hundred in 30 Tests.
"I hope people have seen that England are prepared to fight," said Vaughan. "Kevin's innings was tremendous in the circumstances."