Pakistan won the toss and chose to bat in the fourth day-night international against South Africa at Multan Stadium here on Friday.
The home team made one change from the line-up of Tuesday's third match at Faisalabad with paceman Mohammad Asif coming in for Sohail Tanveer.
Asif is still having problems with an elbow injury, which forced him to sit out the first three matches of the series.
South Africa made two changes, bringing in paceman Andre Nel and Jean-Paul Duminy in place of Justin Kemp and Charl Langeveldt.
Pakistan lead the series 2-1 after back-to-back wins in Lahore and Faisalabad. South Africa won the first match, also played in Lahore.
South Africa: Graeme Smith (capt), Herschelle Gibbs, Jacques Kallis, AB de Villiers, Jean-Paul Duminy, Mark Boucher, Albie Morkel, Makhaya Ntini, Shaun Pollock, Andre Nel, Johan Botha
Pakistan: Shoaib Malik (capt), Yasir Hameed, Kamran Akmal, Younis Khan, Misbah-ul Haq, Shahid Afridi, Mohammad Yousuf, Mohammad Asif, Rao Iftikhar, Umar Gul, Abdul Rehman
Umpires: Billy Bowden (NZL) and Aleem Dar (PAK)
TV umpire: Zamir Haider (PAK)
Match Referee: Alan Hurst (AUS)