Pakistan suffered a big blow hours before the team's departure to India when fast bowler Mohammad Asif pulled out with an elbow injury, officials said.
Asif will miss at least the start of the five-match one-day series but hopes to be fit for the three Tests against Pakistan's biggest rivals.
"Asif has a recurrence of an elbow injury and he will not travel to India with the team," Pakistan Cricket Board (PCB) chief operating officer Shafqat Naghmi told reporters.
The 24-year-old initially suffered the injury to his bowling arm ahead of Pakistan's first Test against England at Lord's last year. It recurred during Pakistan's home series against South Africa earlier this month.
Asif missed the first three one-day internationals before selectors risked him in the fourth one-dayer at Multan where he conceded 64 runs in eight overs and aggravated the injury.
"It's a big loss," Pakistan captain Shoaib Malik told reporters.
"We will try to overcome the loss and hope that it would not affect team's performance in the series," said Malik.
Naghmi said there will be no replacement for Asif in the 15-man squad as he may be fit after the first three matches. Asif will undergo a rehabilitation programme devised by his doctor, Naghmi said.
He justified Asif's inclusion in the match against South Africa.
"Asif was feeling well so he was played in that match but unfortunately felt pain after the match and was rested in the fifth and final match last week," said Naghmi.
Asif has taken 51 wickets in 11 Tests since making his Test debut against Australia three years ago. He also has 31 wickets in 29 one-day internationals.
Pakistan fly out to India on Thursday afternoon to play five one-day internationals and three Tests. The first one-dayer will be played at Guwahati on Monday.
Asif said missing the one-day series is a big disappointment.
"It is a big disappointment because a tour to India is always important and I wanted to be part of the team," Asif told AFP.
"My doctor and our trainer David Dwyer have given me a detailed programme and I will extensively follow that because I want to be the part of the tour. I hope to be fit for the Tests," said Asif.
Asif also missed Pakistan's last tour to India in 2005 because of a knee injury.
His first and only tour to India last year ended in shame as he was withdrawn from the team after he and fellow paceman Shoaib Akhtar tested positive for banned steroid nandrolone.
A PCB doping tribunal banned Akhtar for two years and Asif for one year. The bans were overturned on appeal.