Yousuf and Malik revived Pak innings with a run-a-ball 145-run stand for the fourth wicket after Bangla opening attack Reza and Mortaza struck in regular intervals to leave hosts reeling on 70/3.
Yousuf's 103-ball knock was inclusive of 11 hits to fence while Malik belted 7 boundaries.
Misbah (38 off 27 balls) and Afridi ( 27 off 11, 2X4s&2X6s) played a little cameo innings in the final overs to take Pak past 300 runs.
Bangla new-ball bowlers Mortaza and Reza bowled exceptionally well on a unforgiving lahore strip to return with 2/52 and 2/41 respectively.
Pakistan 322/5 (Salman Butt 33, Mohd Yousuf 108*, Shoaib Malik 85*, Misbah-ul-Haq 38, Shahid Afridi 27*; Mashrafe Mortaza 2 for 52, Farhad Reza 2 for 41) Vs Bangladesh