Stephen Fleming and Makhaya Ntini will make debut for Chennai outfit while left-arm seamer Pradeep Sangwan replaces Manoj Tiwary for Daredevils.
The local outfit leads the chart with four wins in as many games while Daredevils placed second with three wins and a loss.
The Chennai batting line-up looks bit brittle in the absence of Aussie stars Matt Hayden and Mike Hussey, who returned to Australia to attend the preparatory camp at Brisbane ahead of Windies tour starting May 22.
However Chennai coach Kepler Wessels has other ideas. ''We knew this was going to happen (Aussie exodus). But we have other equally good players who are equally good," the former South African and Australian batsman said.
Going into the match Daredevils hold a thin edge, over their Southern counterparts, who miss the services of Trans-Tasman stars, with solid batting line-up and a fairly good attack spearheaded by none other than the legendary McGrath.
Chennai Super Kings: Stephen Fleming, Parthiv Patel, Vidyut Sivaramkrishnan, Suresh Raina, M S Dhoni(capt), Badrinath, Albie Morkel, Joginder Sharma, Makhaya Ntini, Manpreet Goni and Mutthiah Muralitharan.
Delhi Daredevils: Virender Sehwag (capt), Gambhir, Shikar Dhawan, A B DeVilliers, Shoaib Malik, Dinesh Karthik, Rajat Bhatia, Yomahesh, Sangwan, Mohd Asif and Glenn McGrath.
Match Officials: Umpires: Billy Bowden and Hariharan. Third umpire: Mark Benson. Match Ref: S Venkatraghavan