Opening bowler Jhulan Goswami was the other Indian cricketer who reached a landmark in Sri Lanka.
She became the second Indian (after Neetu David) and the fourth overall to take 100 ODI wickets.
Mithali, during her impressive 72-ball 66 runs' innings in the final of the Asia Cup yesterday against Sri Lanka notched the feet to lead India to 177-run victory.
She also became the world's fifth highest run-getter in the ODIs.
The 25-year-old Mithali, who started her career in June 1999, has represented India in 98 ODIs. She has scored 3002 runs at an impressive average of 46.90 which also includes two centuries and 23 half centuries with a career best score of 114.
Apart from her good performances in ODIs, Mithali has also scored 572 runs in eight Tests at an average of 52 with a career best of 214.
Australia's Belinda Clark with 4884 runs in 118 matches, leads the list of highest run-getters in ODIs.
The top five run-getters in ODIs (Matches Runs Average 100s 50s):
1. Belinda Clark (Aus) 118 4844 47.49 5 30
2. Caron Rolton (Aus) 122 4261 49.54 7 29
3. Debi Hokley (NZ) 118 4061 41.89 4 34
4. Charlotte Edwards (Eng) 106 3304 36.30 4 25
5. Mithali Raj (Ind) 98 3002 46.90 2 23