Mumbai bowling ace Shaun Pollock, who is not match fit, makes way for Dilhara Fernando. Wicketkeeper-batsman Pinal Shah is in for Rajesh Pawar.
Hyderabad side have left out Gibbs, Styris and Sarveshkumar and drafted in Haladhar Das, Nuwan Zoysa and Chamara Silva.
The resurgent Mumbai side aim for semis' spot while the local outfit out of contention for semis berth hope to salvage pride.
Mumbai Indians: Sachin Tendulkar (capt), Sanath Jayasuriya, Robin Uthappa, Dominic Thornely, Dwayne Bravo, Abhishek Nayar, Yogesh Takawale (wk), Pinal Shah, Rohan Raje, Dilhara Fernando and Ashish Nehra.
Deccan Chargers: Adam Gilchrist (capt&wk), Shahid Afridi, Halhadar Das, Rohit Sharma, Venugopal Rao, Ravi Teja, Chamara Silva, Nuwan Zoysa, Pragyan Ojha, RP Singh and P Vijaykumar.