In just two Tests at Lancashire's headquarters, against Pakistan in 2006 and the West Indies last year, left-armer Panesar has taken 18 wickets on a pitch which offers assistance for both spinners and fast bowlers alike.
Now he is hoping to exploit the turn and bounce offered at Old Trafford as England look to take a 1-0 lead in the three-Test series following a draw at Lord's where Panesar didn't have a major impact.
"This is one of my favourite grounds," Panesar told reporters here Wednesday. "I've had success here and I'm going to be looking forward to bowling here coming into this Test.
"I enjoy bowling here because the wicket has a bit of pace and bounce and my style of spin suits this kind of wicket and my record shows that," the 26-year-old Northamptonshire bowler added.
"I've had success here and hopefully I can build on that and do well in this Test match. I like the pace of the wicket here because the ball often gathers pace after bouncing and it turns quite sharply - my kind of pace suits this kind of wicket," Panesar explained ahead of Friday's start.
But someone else who will be looking forward to bowling at Old Trafford is New Zealand captain and Panesar's fellow left-arm spinner Daniel Vettori.
A more experienced bowler than his English counterpart, Vettori was named man-of-the-match at Lord's for a superb first innings haul of five for 69 on a pitch which gave him precious little help.
Panesar, who will be playing in his 28th Test on Friday compared to Vettori's 82nd, said there was no substitute for experience.
"He's played international cricket for ever and I suppose with us both being left-arm spinners it's natural to compare but I think it's a bit unfair.
"I've only just started in international cricket and he's played for years, he knows his craft and I look up to him and maybe in a few years time I can emulate what he does.
"I look at him and see how he bowls and the success he's had in all forms of the game - it's refreshing to see another left-arm spinner do well."