The hosts, chasing a revised 204-run victory target from 41 overs after rain stopped proceedings half-way thro the innings, managed a pedestrain 140/8. Chanderpaul again left stranded on 77-ball 45. Powell and Benn made an unbeaten 21 and 23 respectively in a losing cause.
Clarke was the pick of Aussie bowlers with 3/26 in six overs. Watson claimed 2/22.
Earlier Australia laboured to 213/5 on a painfully-slow wicket. Hussey top-scored with a patient 105-ball 62 while Clarke knitted 56 lin 98 balls inclusive of six boundaries. The duo revived Aussie innings with a turtle-esque but sensible 100-run stand. However it was Cameroon White who saw his side past 200 with a rapidfire 40.
Windies got off to a disasterous start as Xavier Marshall was out first ball. Debutant wicketkeeper Luke Ronchi - who replaced the injured Brad Haddin at the last minute - had a dream start to his career as he took the catch off Brett Lee.
The first change bowler Johnson removed the dangerous Gayle caught Ponting at mid-off.
Andre Fletcher was next to go after a wild swing saw him bowled by James Hopes for 19, and Dwayne Bravo soon followed for just three, caught at deep midwicket by Michael Hussey off Shane Watson's delivery.
Clarke then swung the game completly in Australia's favour plucking two wickets in three balls. The left-arm spinner dismissed Patrick Browne caught by White and a ball later accounted for Pollard's wicket after Watson held onto the easy offering at mid-off.
Rain stopped the play in 27th over, and the revised target of 204 left the hosts needing an improbable 146 from 14 overs and that too on a sluggish wicket.
Earlier Windies seamers Taylor (2/47), Powell (1/29) and Bravo (1/35) bowled a probing line to limit the visitors to a modest 214.
Taylor struck in the first over of the game to dismiss Watson for duck and four overs later Powell sent Marsh (12) packing for a regulation caught behind. Ponting (13) in his 300th ODI played a lazy pull off Taylor only to find Gayle's safe pair of hands at mid-wicket to leave Australia in a spot of bother at 34/3 in 9th over.
Hussey joined Clarke in the middle and played sensibly on a hostile wicket. The duo worked the ball in gaps for singles and twos and knitted a sluggish but valuable 100 runs. Clarke stroked six boundaries in his 98-ball knock while Hussey's more sedate knock had two hits to fence and one over it. White run-a-ball 40 ensured Australia a fighting total.
The hosts must win the next one-day international at Grenada's National Stadium on Sunday to keep the series alive, or risk a whitewash.