In the Federation International Cricketers' Associations (FICA) report released on Thursday, 52 per cent of those polled said they would be willing to quit the traditional forms to pursue IPL riches.
The FICA findings are in line with a recent poll conducted by the Professional Cricketers' Association (PCA) that half of England's leading players would consider quitting international cricket early to play in the IPL.
World cricket chiefs are meeting in Dubai this weekend hoping to safeguard the game's future amid a lucrative Twenty20 revolution fuelled by the sport's economic powerhouse India.
The FICA survey targeted 105 international players and received 64 responses.
FICA chief executive Tim May said the emergence of IPL and the 'rebel' Indian Cricket League (ICL), and the potential conflict of fixtures, could result in leading players leaving the international game.
"It is important that such conflicts are avoided by the creation of a window in the international programme," May said.
"This is not to say the introduction of Twenty20 cricket is all negative - it is far from that.
"Cricket's biggest challenge is to find a satisfactory balance between the established forms of the game and Twenty 20."
Most international cricketers want Test matches to remain the sport's priority and believe the Twenty20 boom will affect the one-day game more than Test cricket, the survey also found.
May, a former Australian Test off-spinner, said the process of constructing the ICCs Future Tours Programme (FTP) beyond 2012 was crucial to achieving that balance.
The survey comes at a time where Twenty20 is bringing an extraordinary cash influx into the game with the creation of the ICL and the officially-backed IPL, both of which offer players huge pay days.