The matches are being played this week here in the celebration of Israel's 60th anniversary.
After capitulating for just 52 runs on Sunday, the Israel team should be proud to have scored 233 all out, but was still well short of India's 313/5.
India-A now lead the three-match series 2-0 and the Israel Invitation XI will only have pride to play for in the third and final match here on Tuesday.
"It was an excellent performance and I hope for even better in the final match," Israel Cricket Association (ICA), chairman, Stanley Perlman said.
The ICC Associate Member, Israel, is made up of Jewish cricketers from all round the world, including former South African international Adam Bacher.
Bacher put in a superb batting performance for the hosts, scoring 74 runs off 57 balls in an innings which included a massive eight sixes.
The 38-year-old Rhodes, former South Afican legend, was also included in the squad but retired injured yesterday after scoring three runs before pulling a hamstring. He was adjudged run-out.
The Indian team, which includes fringe players and those who have caught the eye of the Indian selection committee during the recent Indian Premier League tournament, won the toss and elected to bat.
M Vijay top-scored for the visitors with 76 runs while Cheteshwar Pujara, the 20-year old who finished as the 2006 U-19 World Cup's highest scorer, was not far behind with 74 runs.
Rajat Bhatia showed his all-round skills by scoring 55 with the bat, before taking three Israeli wickets.
After India A completed its innings in 50 overs the Israelis came into bat full of confidence. While Bacher took control, Molins was also impressive, scoring 55.
But the opening pair could not do enough to inspire their teammates to victory and the Israelis were bowled out far off their target.
India-A 313/5 in 50 (M Vijay 76, Cheteshwar Pujara 74, Rajat Bhatia 55) beat Isreal 233 all out (Adam Bacher 74, Molins 55).