Earlier, SA skipper Graeme Smith, who is in good nick in the ensuing series, was cleared of back injury he suffered during a warm-up game against Bangla-A last week.
The tourists have made one change to the squad that won the second Test at Leeds to take 1-0 lead in four-Test series with injured pacer Dale Steyn making way for Andre Nel.
Collingwood and Sidebottom return to the England fold in place of Darren Pattinson and Stuart Broad
South Africa, who led their previous three series in England in 1994, 98 and 2003, aim to break English jinx while the hosts hope to win this game to remain alive in the four-Test series
England: Michael Vaughan (capt), Andrew Strauss, Alastair Cook, Kevin Pietersen, Ian Bell, Paul Collingwood, Andrew Flintoff, Tim Ambrose (wk), Ryan Sidebottom, James Anderson and Monty Panesar.
South Africa: Graeme Smith (capt), Neil McKenzie, Hashim Amla, Jacques Kallis, Ashwell Prince, AB de Villiers, Mark Boucher (wk), Paul Harris, Morne Morkel, Andre Nel and Makhaya Ntini.
Match Officials: Umpires: Aleem Dar (Pak) and Steve Davis (Aus). Third umpire: Ian Gould. Match Referee: Ranjan Madugalle (SL).