Guha and Gunn combined shared six wickets as India eves, opting to bat first, stumbled to 124 all out in 43.4 overs. Kate Brunt and Holly Colvin claimed two wickets apiece. Skipper Mithali Raj top scored for India with a patient 75-ball 44. Amita Sharma made run-a-ball 34.
In reply England eves riding of the knocks from Caroline Atkins (45) and Sarah Taylor (40*), hunted down the measly target in 36 overs losing only both the openers in the process.
England, yet to lose a game in a magnificent summer thus far, having beaten the Windies and South Africa, continued there winning streak with a disciplined effort both with the bat and ball.
India, electing to bat in their first overseas tour this summer, were immediately in trouble when Jaya Sharma departed lbw third ball to Guha without scoring, with incoming batsman Asha Rawat also following the suit for a duck.
Guha's new ball attack partner Kate Brunt sent Sulakshana Naik caught Sarah Taylor for 5. The opening burst of new ball attack left India eves reeling on 6/3.
Amita Sharma and Mithali Raj attempted to rebuild Indian innings with a 48-run stand before the Buckinghamshire-born English medium pacer of Indian origin returned to bowl her second spell and foiled the Indian plans by removing Amita Rawat.
Gunn, introduced late in the innings, got into wicket-taking act immediatly as India collapsed to 124.
The teams will travel to Tauntan for the second ODI to be played on Sept 1.
India eves 124 all out in 43.4 overs (Mithali Raj 44, Amita Rawat 34; Isa Guha 3/30, Jenny Gunn 3/13) lost to England 125/2 in 36 overs (Caroline Atkins 45, Sarah Taylor 40 n o; Nandini Nagarajan 1/10).