At stumps, the hosts had taken a strong 384-run lead with Rajat Bhatia batting on 32 and giving him company was Mayank Tehlan on 24 after Kohli fell three runs short of a well-deserved double hundred, while Chopra was dismissed on 185 by Adil Raza.
Both the overnnight batsmen carried on from where they had left last evening and dominated the bowling throughout their stay at the wicket.
Chopra and Kohli played cautiously in the morning and did not give their counterparts any chance to stage a comeback into the match.
Kohli was cleaned up by Asad Ali when he was on 197 and looked set for a double century, while Chopra's stumps were rattled by Adil Raza but not before the two had put the hosts in the driving seat.
It was a tough day in office for the Pakistani side who, on day one had bundled out the hosts for a paltry 134.
Kohli's innings was punctuated by 29 effortless hits to the fence and a six, while former India opener Chopra had 21 fours in his 385-ball innings.
Howevr, Sehwag was in no mood to declare early with such a formidable lead and only a day left in the match.
The Pakistanis had to chase leather the whole day and at times their actions were evident enough to show that they were in total dejection.
Just when it looked that Sehwag might declare the innings, the heavens opened and a heavy downpour came to the rescue of the visitors.
For the Pakistani team, Asad Ali claimed Kohli and Mithiun Manhas' (10) wickets while the first innings' hat-trick boy Imran Ali and Adil Raza scalped a wicket each.