Headingley: England captain Andrew Strauss won the toss and elected to bat in the fourth test at Headingley on Friday.
Steve Harmison replaces Flintoff for England, who are leading 1-0 in the Ashes.
Australia made two changes to their side, bringing in Stuart Clark and Brad Haddin for Nathan Hauritz and Graham Manou, while Brett Lee missed out despite regaining full fitness.
England (Playing XI): Andrew Strauss(c), Alastair Cook, Ravinder Bopara, Ian Bell, Paul Collingwood, Matthew Prior(w), Stuart Broad, Graeme Swann, Stephen Harmison, James Anderson, Graham Onions
Australia (Playing XI): Simon Katich, Shane Watson, Ricky Ponting(c), Michael Clarke, Mike Hussey, Marcus North, Brad Haddin(w), Mitchell Johnson, Ben Hilfenhaus, Peter Siddle, Stuart Clark