Chargers will look to upset MS Dhoni's men after clinching the double-win over Pune Warriors India.
Despite a decent start to the season, MS Dhoni's men have slumped to two consecutive defeats at home to Kings XI Punjab and Kolkata Knight Riders.
Inconsistent batting at the middle order and bowling failures have forced them below the top-four to fifth position in the points table with nine points in 10 matches.
Middle-order batting woes continued with IPL's top-scorer Suresh Raina's poor show continued to haunt the reigning champions.
Million dollar boy Ravindra Jadeja has so far scored 145 runs in eight innings and except for his five-wicket haul against the Chargers, the most expensive player in IPL 5 remains a flop.
Apart from Faf du Plessis, opener S Badrinath is the only batsman to score a half century in six innings, but the arrival of Australia's Mike Hussey has seen his demotion to the middle-order after scoring only 147 runs.
Local hero R Ashwin has failed to extract turn on a slow track. Ashwin has so far claimed five wickets on 10 innings at an average of 43.80. Australian pacer Doug Bollinger may have taken the highest wickets (7) but has also conceded the most number of runs with a economy rate of 8.72 in six games.
Dhoni and Co have been retaining the same squad for several matches but it's the right time to take some calculated risks and change things in the middle.
Deccan Chargers remain at the bottom of the table with five points after completing a double-win over Pune Warriors India. Skipper Kumar Sangakkara and Cameron White seem to have found their touch back with an impressive 157-run partnership against Ganguly's XI.
The Hyderabad based team will be confident against Chennai as the defending champions lost two in a row in their own backyard.
Chennai Super Kings: MS Dhoni (captain, wicketkeeper), Srikkanth Anirudha, Ravichandran Ashwin, Subramaniam Badrinath, George Bailey, Doug Bollinger, Dwayne Bravo, Faf du Plessis, Ben Hilfenhaus, Michael Hussey, Ravindra Jadeja, Shadab Jakati, Joginder Sharma, Suraj Randiv, Nuwan Kulasekara, Yo Mahesh, Albie Morkel, Suresh Raina, Wriddhiman Saha, Scott Styris, Sudeep Tyagi, Kuthethurshri Vasudevadas, Ganapathi Vignesh, Murali Vijay.
Deccan Chargers: Kumar Sangakkara (captain), Cameron White, Shikhar Dhawan, JP Duminy, Manpreet Gony, Daniel Harris, Parthiv Patel, Dale Steyn, Rusty Theron, Ishank Jaggi, Abhishek Jhunjhunwala, Chris Lynn, Amit Mishra, Tanmay Mishra, Ashish Reddy, Anand Rajan, Ankit Sharma, Tekkami Atchuta Rao, Akash Bhandari, Bharat Chipli, Daniel Christian, Kedar Devdhar, Veer Pratap Singh, Syed Quadri, Dwaraka Ravi Teja, Akshath Reddy, Biplab Samantray, Sneha Kishore, Sunny Sohal, Tanmay Srivastava, TP Sudhindra, Arjun Yadav.