The Australian all-rounder's announcement follows Australia's ICC Women's World Cup finals win in India on Sunday, beating the West Indies by 114 runs. In her final match for Australia, Sthalekar took 2/0 and wrapped up the win with a fine catch to dismiss the last West Indian batter.
Sthalekar, who was born in Pune on August 13, 1979, made her international debut in 2001 in a One Day International (ODI) match against England. She went on to play for Australia in eight Tests, 125 ODIs and 54 Women's T20 International matches.
Sthalekar said the decision to retire from international cricket did not come easy.
"To finish my international career by playing in a successful ICC Women's World Cup in the country of my birth is quite special for me," Sthalekar said.
"I feel that this is the right time for me to retire and I've been fortunate to be able to represent Australia for as long as I have and to have been a part of some very successful teams. Women's cricket has changed a lot during my time in the game and it's been an honour to witness this evolution first hand. We have seen at this year's World Cup that the standard of women's cricket across the world has grown immensely in the last few years alone.
"I would like to continue my involvement in all aspects of the game following my retirement. Cricket has given me a great deal during my life and I want to be able to give something back, whether it be through coaching, mentoring or other avenues.
"I am looking forward to the next phase of my life and the opportunity to help women's cricket continue to develop."
The talented all-rounder has made a name for herself with both the bat and ball throughout her career. She has amassed a total of 416 Test runs, 2728 ODI runs and 769 T20 international runs. Her bowling statistics are equally impressive, having claimed 23 wickets at Test level, 146 at ODI level and 60 in T20 international matches. She was the first woman to score 1,000 runs and take 100 wickets in ODIs.
She has also enjoyed a great deal of success with the national side, having been a part of the winning teams in the ICC Women's World Cup in 2005 and 2013 and the ICC Women's World Twenty20 in 2010 and 2012. She was also vice-captain of the national side from 2006 - 2009.